Document Details
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Document Type |
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Thesis |
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Document Title |
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ANGIOGENIC BIOMARKERS IN PREGNANCY ASSOCIATED WITH GESTATIONAL DIABETES دراسة المؤشرات الحیویة في بناء الاوعية الدموية لدى النساء المصابات بسكر الحمل |
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Subject |
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Faculty of Applied Medical Sciences |
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Document Language |
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Arabic |
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Abstract |
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Background: Any level of glucose intolerance typically occurring during the third trimester of pregnancy is gestational diabetes mellitus (GDM). Placental angiogenesis is not a pathological process but a normal physiological process. For placental growth, a branched vascular network is essential, and is dependent on multiple angiogenic factors. The goal of the present research was to investigate the rates of expression of five fundamental angiogenic biomarkers called vascular endothelial growth factor-A (VEGF-A), angiopoietin-2, endoglin, endothelin-1, and granulocyte colony-stimulating factor (G-CSF) and to determine the role of these angiogenic factors in predicting clinical outcomes in GDM.
Materials and methods: The participants were pregnant women with GDM (GDM; n=10) which usually arise after the 24th week of gestation and pregnant women without GDM (normal pregnants(NP); n=9) as normal control to compare results. Angiogenic biomarkers multiplex assay from Milliplex was used to assess the levels of VEGF-A, endoglin, endothelin-1, angiopoietin-2 and G-CSF in serum samples. All data were statistically analyzed using an unpaired student t-test. Correlations between measured parameters were made using Pearson correlations.
Results: In the current study, VEGF-A, endoglin, endothelin-1, and angiopoietin-2 levels in GDM were significantly higher (P value = 0.001, 0.042, 0.049, 0.001; respectively) compared to control healthy pregnant women. However, G-CSF level exhibited non-significant increase (P=0.466) in GDM compared to healthy controls. In the present study, the Pearson correlation test for all correlations in GDM were used. There was positive significant correlation between angiopoietin -2 with endoglin, endothelin-1, and VEGF-A. Moreover, there was positive significant correlation between VEGF-A with endoglin and endothelin-1. Most interestingly, there was positive significant correlation between G-CSF with endothelin-1.
Conclusion: The current study revealed that angiogenic factors were highly altered in pregnant women with GDM. The current study will help in monitoring affected pregnant women and fetuses during and after delivery and help to decrease exposure to complications accompanied with GDM. |
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Supervisor |
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Dr. Azizah Alrafiah |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1441 AH
2020 AD |
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Added Date |
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Wednesday, June 24, 2020 |
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Researchers
| سلمان موسى معيدي | Muyidi, Salman Mousa | Researcher | Master | |
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