Document Details

Document Type : Article In Journal 
Document Title :
Microarray expression profiling identifies genes, including cytokines, and biofunctions, as diapedesis, associated with a brain metastasis from a papillary thyroid carcinoma
Microarray expression profiling identifies genes, including cytokines, and biofunctions, as diapedesis, associated with a brain metastasis from a papillary thyroid carcinoma
 
Document Language : English 
Abstract : Brain metastatic papillary thyroid carcinomas (PTCs) are afflicted with unfavorable prognosis; however, the underlying molecular genetics of these rare metastases are virtually unknown. In this study, we compared whole transcript microarray expression profiles of a BRAF mutant, brain metastasis from a PTC, including its technical replicate (TR), with eight non-brain metastatic PTCs and eight primary brain tumors. The top 95 probe sets (false discovery rate (FDR) p-value < 0.05 and fold change (FC) > 2) that were differentially expressed between the brain metastatic PTC, including the TR, and both, non-brain metastatic PTCs and primary brain tumors were in the vast majority upregulated and comprise, e.g. ROS1, MYBPH, SLC18A3, HP, SAA2-SAA4, CP, CCL20, GFAP, RNU1-120P, DMBT1, XDH, CXCL1, PI3, and NAPSA. Cytokines were represented by 10 members in the top 95 probe sets. Pathway and network analysis (p-value < 0.05 and FC > 2) identified granulocytes adhesion and diapedesis as top canonical pathway. Most significant upstream regulators were lipopolysaccharide, TNF, NKkB (complex), IL1A, and CSF2. Top networks categorized under diseases & functions were entitled migration of cells, cell movement, cell survival, apoptosis, and proliferation of cells. Probe sets that were significantly shared between the brain metastatic PTC, the TR, and primary brain tumors include CASP1, CASP4, C1R, CC2D2B, RNY1P16, WDR72, LRRC2, ZHX2, CITED1, and the noncoding transcript AK128523. Taken together, this study identified a set of candidate genes and biofunctions implicated in, so far nearly uncharacterized, molecular processes of a brain metastasis from a PTC. 
ISSN : 5088-2820 
Journal Name : American journal of cancer research 
Volume : 6 
Issue Number : 10 
Publishing Year : 1437 AH
2016 AD 
Article Type : Article 
Added Date : Wednesday, July 12, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Hans-Juergen SchultenSchulten, Hans-Juergen ResearcherDoctorate 
Deema HusseinHussein, Deema ResearcherDoctorate 
Fatima Al-AdwaniAl-Adwani, Fatima ResearcherDoctorate 
Sajjad KarimKarim, Sajjad ResearcherDoctorate 
Jaudah Al-MaghrabiAl-Maghrabi, Jaudah ResearcherDoctorate 
Mona Al-SharifAl-Sharif, Mona ResearcherDoctorate 
Awatif JamalJamal, Awatif ResearcherDoctorate 
Sherin BakhashabBakhashab, Sherin ResearcherDoctorate 
Jolanta WeaverWeaver, Jolanta ResearcherDoctorate 
Fahad Al-GhamdiAl-Ghamdi, Fahad ResearcherDoctorate 
Saleh S BaeesaBaeesa, Saleh SResearcherDoctorate 
Mohammed BangashBangash, Mohammed ResearcherDoctorate 
Adeel ChaudharyChaudhary, Adeel ResearcherDoctorate 
Mohammed Al-QahtaniAl-Qahtani, Mohammed ResearcherDoctorate 

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