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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
INCREASED FIBRIN TURNOVER IN PERIPHERAL ARTERIAL DISEASE: COMPARISON WITH A POPULATION STUDY
INCREASED FIBRIN TURNOVER IN PERIPHERAL ARTERIAL DISEASE: COMPARISON WITH A POPULATION STUDY
Subject
:
Vascular Surgery
Document Language
:
English
Abstract
:
Copley hypothesised the existence of an endoendothelial fibrin lining of blood vessels; while the Rokitansky-Duguid hypothesis suggests that ongoing fibrin formation on the arterial wall contributes to atherosclerosis. We assessed in vivo fibrin turnover by measurement of plasma levels of cross-linked fibrin degradation products (D-dimer antigen) using a sensitive immunoassay, in 68 patients with extensive atherosclerosis (chronic peripheral arterial disease) compared to 239 controls (a random population sample in the same area). Plasma D-dimer levels were significantly higher in patients than controls (p(O.OI) and correlated with clinical severity. We suggest that the plasma D-dimer level may be a useful index of intravascular fibrin turnover and of the ongoing contribution of thrombosis to arterial disease.
ISSN
:
1836-0291
Journal Name
:
Clinical Hemorheology
Volume
:
12
Issue Number
:
1
Publishing Year
:
1412 AH
1992 AD
Article Type
:
Article
Added Date
:
Monday, August 24, 2009
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
حسن الزهراني
Al-Zahrani, Hasan
Investigator
Doctorate
Files
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Type
Description
20320.pdf
pdf
Increased fibrin turnover
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